Asian Journal of Pharmacy and Technology

Vishal Mahanur ¹, Rahul Rajge ¹, Mukund Tawar ¹

Affiliations
1 Department of Pharmaceutics, P. R. Pote Patil College of Pharmacy, Amravati – 444604, IN

Abstract

The initial pass metabolism or pre-circulatory system is a metabolic process in which the concentration of the drug is significantly reduced or shortened in the liver before it reaches the circulatory system. A fraction of the drug lost in the entire absorption process is often associated with the liver and skin wall. Oral delivery, the simplest form of drug management has its limitations, most of which are the low availability of drugs due to the first internal organ passing through metabolism. Drugs with low bioavailability need to be administered at a better dose as a small fraction of the controlled dose is injected into the bloodstream and reaches the target. Therefore, the worst dose of the drug is destroyed and the unauthorized drug ends up having unwanted side effects within the canal. Various forms of oral contraceptives are used. The current review focuses on the importance of passing the first hepatic pass, the biological findings, the reasons for the negative findings and the various methods used to skip the initial hepatic pass metabolism.

Keywords

Hepatic First Pass Metabolism, Bioavailability, Novel Drug Delivery System, Low Bioavailability, Gut Wall, Site Targeted

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